Titia de lange

Dr. Titia de Lange (Leon Hess Professor and Head of the Laboratory of Cell Biology and Genetics at Rockefeller University and Ellison Medical Foundation Senior Scholar in Aging in 1998) was honored with the 2011 Vilcek Prize in Biomedical Research for her research on telomeres, the specialized structures that cap the ends of chromosomes and play a vital role in maintaining genome stability and Titia de Lange was born in the Netherlands and studied biochemistry at the University of Amsterdam. She moved to the US in 1985, joining Harold Varmus' laboratory at UCSF for postdoctoral work.

Cancer genomes often harbor hundreds of somatic DNA rearrangement junctions, many of which cannot be easily classified into simple (e.G. Deletion, translocation) or complex (e.G. Chromothripsis, chromoplexy) structural variant classes. Applying a novel genome graph computational paradigm to analyze the topology of junction copy number (JCN) across 2,833 tumor whole genome sequences … Titia de Lange (Rotterdam, 11 november 1955) is een Nederlandse celbioloog en geneticus, bekend om haar wetenschappelijk werk over telomeren. Titia de Lange, hoogleraar aan de Rockefeller University in New York, Verenigde Staten, ontving de Dr. H.P. Heinekenprijs voor de Biochemie en Biofysica 2012 voor haar onderzoek naar 'telomeren', de beschermende uiteinden van chromosomen die onder meer … Titia de Lange . Calendar. Add to Calendar Add to Timely Calendar Add to Google Add to Outlook Add to Apple Calendar Add to other calendar Export to XML When: September 19, 2016 @ 12:00 pm – 1:00 pm 2016-09-19T12:00:00-04:00. 2016-09-19T13:00:00-04:00. Where: Main Auditorium Titia de Lange The Rockefeller University. Election Year: 2006 Primary Section: 41, Medical Genetics, Hematology, and Oncology Membership Type: International Member: Research Interests. The linear chromosomes of eukaryotes pose two fundamental problems. Because the universal DNA replication strategy fails to copy chromosome ends, they require a Titia de Lange's lab has identified many of the components of shelterin and studies how its components work together to ensure that chromosome ends are not recognized as DNA breaks. Titia de Lange's 10 research works with 159 citations and 650 reads, including: Characterization of t-loop formation by TRF2 Dutch cell biologist Dr. Titia de Lange is one of the world’s leading experts on telomeres. Her honors are many and include some of the most prestigious science awards, such as the Canada Gairdner International Award, the Dr. H.P. Heineken Prize for Biochemistry and Biophysics, and the Breakthrough Prize in Life SciencesCanada Gairdner

Titia de Lange (born 11 November 1955, in Rotterdam) is a professor of Cell Biology and Genetics at Rockefeller University.. De Lange obtained her Masters on "Chromatin structure of the human -globin gene locus" at the University of Amsterdam in 1981, and subsequently her PhD at the same institution in 1985 with Piet Borst on surface antigen genes in trypanosomes.

@MISC{Wu08contentalerts, author = {Peng Wu and Titia De Lange and Deprotected Telomeres}, title = {CONTENT ALERTS}, year = {2008}} Share. OpenURL . Abstract. This article cites 46 articles, 18 of which can be accessed free. Keyphrases. Content alert Powered by: …

Titia de Lange Titia de Lange was born in the Netherlands and studied biochemistry at the University of Amsterdam. She did undergraduate work with Richard Flavell at the National Institute of Medical Research in London and obtained her graduate degree with Piet Borst at the Dutch Cancer Center. Titia de Lange 1; The Rockefeller University, New York, New York 10021, USA... Celli and de Lange 2005; G. Celli, E. Denchi, and T. De Lange, unpubl.). Cells lacking DNA ligase IV or Ku70 have a 10- to 50-fold reduced ability to fuse telomeres after shelterin inhibition. The other NHEJ proteins, DNA-PKcs, XRCC4, and Ku80, are presumed to be Yanowitz Lab Photo : Judth Yanowitz, Ph.D. Principal Investigator. Dr. Yanowitz received her B.S. In biology with a minor in literature from MIT in 1991, worked for two years in Titia de Lange’s laboratory at Rockefeller University studying telomere biology. Image: Titia de Lange laboratory: The protein in question is part of a complex called shelterin, which prevents a potentially dangerous type of DNA repair that can shorten telomeres and therefore cause cells to age quickly. Alternatively, the repair process can help elongate telomeres in … Ms. Titia de Lange was Member of the Board of Directors of Nestle SA since 2010. She passed Doctoral exams with highest honors at Universiteit van Amsterdam and National Institute for Medical Research in 1981. In 1981 she also obtained Doctorate in Philosophy degree in Biochemistry cum laude at Universiteit van Amsterdam and The Netherlands Titia de Lange (* 1955 in Rotterdam) ist eine niederl ndisches Krebs-Institut) einen Ph.D. In Biochemie.Als Postdoktorandin arbeitete sie bei Harold Varmus an der University of Titia de Lange describes herself as a puzzler, someone who “lives the question,” rather than focusing on the solution. The puzzle that de Lange has been working on since the late ‘80s is telomeres: highly specialized DNA-protein structures that cap the ends of linear chromosomes, protecting from degradation and maintaining chromosome stability. CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Telomere length in human cells is controlled by a homeostasis mechanism that involves telomerase and the negative regulator of telomere length, TRF1 (TTAGGG repeat binding factor 1). Here we report that TRF2, a TRF1-related protein previously implicated in protection of chromosome ends, is a second negative regulator "The 'old' idea in cancer is that it arose from a first bad mutation, and then a second mutation, and a third, and so on, until the cells divide uncontrollably, leading to cancer," says Titia de Category:Titia de Lange. From Wikimedia Commons, the free media repository. Jump to navigation Jump to search. Titia de Lange NPDA page 1 Titia de Lange A new approach to the DNA damage response Significance The biological response to DNA damage is a central issue in modern biology that has attracted the attention of …

From unruly teenager and poor high school student, to international award-winning scientist: this was the story that Dr. Titia de Lange (above) told us about in her two lectures, delivered on October 27th as part of the Gairdner Foundation program.

The Rockefeller cell biologist and geneticist will give a talk at Stanford titled “Telomeres and the DNA damage response.” Double-strand breaks in DNA (DSBs) are among the most lethal lesions in the genome if they are not repaired or if their repair is executed incorrectly. Most cancer therapies, including radiation thera... De Lange is a Dutch surname, meaning "the tall one". In 2007 about 11,000 people in the Netherlands carried the name. People with this surname include: Allert de Lange [de; fr; nl] (1855-1927), Dutch publisher and book dealer; Andre de Lange (born 1984), South African cricketer; Bob de Lange [de; fy; nl] (1916-1978), Dutch actor; Con de Lange (born 1981), South African cricketer From 1985 to 1990, Dr. De Lange was a postdoctoral fellow in the laboratory of Dr. Harold Varmus at UCSF, where she was one of the first scientists to isolate human telomeres. Dr. De Lange joined The Rockefeller University in 1990 as an Assistant Professor. She was appointed a tenured Professor in 1997 and the Leon Hess Professor in 1999. Image: Titia de Lange laboratory: The protein in question is part of a complex called shelterin, which prevents a potentially dangerous type of DNA repair that can shorten telomeres and therefore cause cells to age quickly. Alternatively, the repair process can help elongate telomeres in … The Titia de Lange Lab has deposited plasmids at Addgene for distribution to the research community. Addgene is a nonprofit plasmid repository dedicated to improving life science research. Learn more about research in the Titia de Lange Lab. Titia de Lange, Ph.D., Director, Anderson Center For Cancer Research, The Rockefeller University, Will Be Keynote Speaker For Gilda's Club NYC 12th Annual Celebrating Women Benefit Luncheon, May 8th - read this article along with other careers information, tips and advice on BioSpace Titia de Lange (born 11 November 1955, in Rotterdam) is the Director of the Anderson Center for Cancer Research, the Leon Hess professor and the head of Laboratory Cell Biology and Genetics at Rockefeller University.De Lange obtained her Masters on "Chromatin structure of the human -globin gene locus" at the University of Amsterdam in 1981, and subsequently her PhD at the same institution in By Katja Kratz, Titia de Lange. Jbc.Org — Comprised of telomeric TTAGGG repeats and shelterin, telomeres ensure that the natural ends of chromosomes remain impervious to the DNA damage response. Telomeres carry a long constitutive 3’ overhang that can bind Replication Protein A (RPA) and activate the ATR Ser/Thr kinase, which induces cell Dr. Titia de Lange is the Leon Hess Professor, an American Cancer Society Research Professor, and the Director of the Anderson Center for Cancer Research at Rockefeller University. After getting her doctorate from the University of Amsterdam, she pursued her postdoctoral training with Dr. Harold Varmus at UCSF. NEW YORK, May 2, 2019 /PRNewswire/ -- Gilda's Club New York City announced the Keynote Speaker for its 12th Annual Celebrating Women luncheon is Titia de Lange, Ph.D., Head of the...

Titia de Lange is a professor of Cell Biology and Genetics at Rockefeller University. De Lange obtained her Masters on "Chromatin structure of the human Ÿ-globin gene locus" at the University of Amsterdam in 1981, and subsequently her PhD at the same institution in 1985 with Piet Borst on surface antigen genes in trypanosomes. Titia De Lange. See Photos. Studied at VU University Amsterdam '09. Titia de Lange. See Photos. Tertia De Lange. See Photos. Studied at Isa Carstens Health & Skincare Academy Titia de Lange Board of Directors Elected to the Board 2010 Date of birth: 1955 Nationality: Dutch Career 2006 Associate Director, Anderson Cancer Center, The Rockefeller University 1999 Leon Hess Professor, The Rockefeller University 1997 Professor, The Rockefeller University 1994 - 1997 Associate Professor, The Rockefeller University

Titia de Lange – Dr. H.P. Heinekenprijs voor de Biochemie en Biofysica 2012 Vroege liefde voor telomeren krijgt erkenning Telomeren zijn, zegt Titia de Lange zelf, haar lust en haar leven. ‘Ik kan eigenlijk niet goed uitleg-gen waarom ik die chromosoomuiteinden zo … Assistant Professor of Cell and Developmental Biology Molecular and Cell Biology, UC Berkeley Postdoctoral Fellow in Genetics (2007-2012) Advisor: Dr. Rudolf Jaenisch, Whitehead Institute Ph.D. In Molecular and Cell Biology (2002-2007) Advisor: Dr. Titia de Lange, Rockefeller University B.S. And M.S. In Biochemistry (1998-2002) Titia de Lange, professor of cell biology and genetics and director of the Anderson Center for Cancer Research at Rockefeller University, has won the 2018 Bert and Natalie Vallee Award in honor of her groundbreaking discoveries of the mechanism by which telomeres shield chromosome ends and of the relationship between telomere dysfunction and cancer.

Titia de Lange was born in the Netherlands and studied biochemistry at the University of Amsterdam. She moved to the US in 1985, joining Harold Varmus’ laboratory at UCSF for postdoctoral work. In 1990, she joined the faculty of the Rockefeller University as an … Year Citation Score; 2018: Mirman Z, Lottersberger F, Takai H, Kibe T, Gong Y, Takai K, Bianchi A, Zimmermann M, Durocher D, de Lange T. 53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. Nature.PMID 30022158 DOI: 10.1038/s41586-018-0324-7 : 0.48: 2017: Takai KK, Kibe T, Donigian JR, Frescas D, de Lange T.Telomere Protection by TPP1/POT1 Requires Tethering